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For example, Aβ peptide interacts with Ryanodine receptors located in the cell body, dendrites, spines, and other parts of nerve cells to increase the activity of Ryanodine receptors, and then the balance of intracellular Ca 2+ homeostasis is destroyed, which causes structural and functional damage of nerve cells and even the death of nerve cells [181]

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Enzymes like NADPH oxidases, xanthine oxidases, cytochrome P450 and other oxidases also produce ROS