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However, findings in a systematic review and meta-analysis of prolonged NSAID use (ranging from one to seven years) indicated NSAIDs accelerate OA progression

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That often includes: Older adults who naturally absorb less B12 from food Vegans and vegetarians who don’t eat enough B12-rich foods People with stomach or gut issues (like Crohn’s or coeliac disease) Those on long-term medication that affects absorption Busy people who feel drained all the time and can’t explain why If you fall into one of these groups, injections might be worth considering