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Continuous ROS production results in oncogene and tumor suppressor gene changes, as well as chromosomal abnormalities by oxidative genome damage, which includes the oxidation of guanine to form 8-OhdG and 8-oxo,7,8-dihydroguanosine (8-OHG) in RNA and DNA (100)

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[DOI] [PubMed] [Google Scholar] 37.Spencer JP, Jenner P, Daniel SE, Lees AJ, Marsden DC, Halliwell B