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Work at the University of Ulm found that on baseline nights, growth hormone secretory bursts closely tracked the appearance of slow-wave sleep, and delaying sleep onset until 2:00 AM delayed the growth hormone bursts with it
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Niacinamide slows the transfer of melanin once it has been made and packaged, and Alpha-Arbutin blocks the enzyme that assembles it, while Tranexamic Acid works one stage earlier still, on the signal that starts the whole process after UV exposure or inflammation