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A patient may have been losing weight consistently with semaglutide, tirzepatide, nutrition changes, increased activity, and medical follow-up—then suddenly the scale Sources American Academy of Allergy, Asthma & Immunology: Mast Cell Activation Syndrome (MCAS) AAAAI Mast Cell Disorders Committee Work Group Report Mast Cell Activation Syndrome: Current Understanding and Research Needs Impact of Polyphenols on Mast Cells with Special Emphasis on Quercetin Effects of Dietary Components on Mast Cells: Possible Use as Supportive Therapy The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation