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Lower NNMT cuts the shift of nicotinic acid (NA) to 1-methylnicotinamide (1-MNA)

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Once cells are stimulated by cytokines, radiative, oxidative, or other types of stress, GSTP1 dissociates from JNK, and the activated JNK mediates phosphorylation of c-Jun, a member of the activated protein-1 (AP-1) transcription complex