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FactorNasal SprayInjectable FormMethod of UseSprayed into the nostrilInjected under the skinNeedle-FreeYesNoHuman Clinical TrialsNone publishedNone well-controlledFDA ApprovalNot approvedNot approvedDosing ConsistencyVaries widely by brandVaries widely by brandAbsorption CertaintyUnclear, theoreticalMore predictable pharmacologically As you can see, neither option has the backing of solid, peer-reviewed human research
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USP Chapter 797 (sterile compounding standards) and manufacturer labeling set the 28-day limit as a conservative in-use period that accounts for: preservative degradation over time, the cumulative risk of septum contamination from repeated needle punctures, and the potential for particulate introduction
