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Metformin also enhances the fluidity of cell membranes (Marc et al., 2014) and inhibits the inflammatory process by increasing plasma fibrinolytic activity, reducing the concentration of plasminogen activator inhibitor-1 (PAI-1), preventing excessive activation of platelets, and reducing endothelial damage (Hirsch et al., 2013

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Glutaminase inhibition in renal cell carcinoma therapy