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Slowly press the plunger so the water runs down the inside of the glass and pools at the bottom around the powder

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An Agilent Poroshell 2.7μm C18 (2.1mm × 100 mm) column was operated with a linear gradient from 2% Methanol/0.01% formic acid to 95% Methanol/0.01% formic acid in 10 min