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These findings indicate that omega-3 and vitamin B12 can counteract several PPA-induced biochemical abnormalities, although the evidence remains limited to an animal model and cannot be directly extrapolated to clinical populations ( The study of Doaei evaluated whether omega-3 supplementation modifies behavioral and social symptoms in children diagnosed with ASD according to DSM IV-TR criteria and ADOS assessment

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In the first decade of the 21st century, the possible lifetime incidence was estimated to be approximately 50% in women and approximately 20% in men [5]