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Data on the unmodified fragment at research doses is more limited

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Basically, the superoxide free radical (for example from leak from complex I in mitochondria and biochemically by reactions involving xanthine/xanthine oxidase or NADPH oxidase) and nitric oxide [NO, formed by catalytic action of nitric oxide synthase (NOS) on arginine] react in a radical-radical recombination to form peroxynitrite, a nonradical (38, 39)