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Desensitization and Tolerance Are Both Associated with Reduction of Functional Receptors Quantitative models (Operational models or Furchgott analysis) used to quantify the loss of functional MOR-effector coupling associated with rapid desensitization of MOR, short-term tolerance, or long-term tolerance to morphine have all calculated that a loss of 80% or more (up to 95%) of functional surface MOR is required to account for the observed shift in morphine concentration-response curves (Chavkin and Goldstein, 1984

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doi: 10.1016/j.jep.2014.12.029 50 GuoP.WangW.XiangQ.PanC.QiuY.LiT.et al