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THE ROLE OF NRF2 IN KIDNEY PHYSIOLOGY Using a transcriptomic and proteomic approach, Shelton and colleagues determined that kidneys from Nrf2 knockout mice are deficient in genes and proteins that regulate glutathione synthesis and conjugation, redox balance, metabolism and removal of xenobiotics, and generation of NAD(P)H (Shelton et al., 2015)

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E., Strupp, B