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Long-term appropriate forms of exercise and appropriate exercise intensity can promote the balance between bone formation and bone resorption, increase bone trabecular alignment and density, accelerate bone mineralization, enhance bone mass, and improve bone metabolism by regulating the signaling molecules secreted by osteoblasts and osteoclasts ( MOTS-c acts as an “exercise mimetic,” and exogenous administration of MOTS-c can exhibit an “exercise-like” effect, therefore protecting the skeleton

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Folkers K, Langsjoen P, Willis R, et al