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This, in turn, activates STAT3 signaling, leading to the upregulation of glycolysis-associated genes, notably independent of CHAC1’s established role in ferroptosis induction (Pan et al., 2024)

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Together, these findings suggest that dopamine receptor signaling is required for maintaining homeostasis and that both types of dopamine receptors can be anti-inflammatory in renal proximal tubule cells, but that the signaling mechanisms mediating the effects of each type of dopamine receptor are likely distinct