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197 For instance, increased blood urea concentrations can alter the microbiome, resulting in the increased generation of toxic metabolites from the gastrointestinal tract as well as an increased tendency for toxins to cross the gut barrier, which can promote further kidney injury
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In diabetic nephropathy, CoQ 10 supplementation modulated gene expression of peroxisome proliferator-activated receptor-γ, interleukin-1, and TNF-α, together with the favorable impacts on glucose metabolism [130,131]