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Additionally, while the interplay between perioperative inflammation, postoperative pain and nonanalgesic outcomes like delirium has been more extensively studied with perioperative nonsteroidal anti-inflammatory drugs [32], NAC is postulated to have similar anti-inflammatory benefits
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NAD + levels increase under conditions that increase lifespan and healthspan, such as dietary restriction and exercise, and decrease during ageing or under conditions that decrease lifespan and healthspan, such as a high-fat diet, which supports the working model that decreased NAD + levels might contribute to the ageing process [57]
