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The degree of inflammation of the colon was graded semiquantitatively from 0 to 11 according to described criteria (Appleyard and Wallace, 1995) taking into consideration (1) loss of mucosal architecture (score 0–3), (2) cellular infiltration (score 0–3) (3) muscle thickening (score 0–3), (4) crypt abscess formation (score 0–1) and (5) goblet cell depletion (score 0–1)