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[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Niesters M, et al

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2 Physiology of normal growth Short stature in children is defined as a height standard deviation score (SDS) lower than - 2 SD, more than 2 SD below a population’s mean for age and sex ( 2.1 GH-IGF-1 axis Regular GH-IGF-1 secretion and functions are fundamental for pre and postnatal growth ( Pituitary GH is encoded by the GH1 gene, and it is secreted in pulsatile manner in the circulation ( Figure 1 )