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The two components of CagriReta investigate complementary biology: GLP-1 receptor agonism GIP receptor agonism glucagon receptor agonism energy expenditure metabolic regulation amylin receptor signalling satiety biology gastric emptying appetite regulation Together these pathways represent four distinct hormonal systems involved in metabolic regulation

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How comfortable one feels with the science propagated on Huberman Lab depends entirely on how much leeway one is willing to give a man who expounds for multiple hours a week on subjects well outside his area of expertise